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Clinical pharmacology studies demonstrate that despite oral bioavailability of less than 1% compared to nearly complete absorption with subcutaneous injection, properly formulated oral tablets containing appropriately higher absolute doses achieve therapeutic blood concentrations sufficient for clinical appetite suppression, gastric emptying modulation, and metabolic effects comparable to injectable administration

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Two weeks ago, the first of the highly anticipated Phase 3 clinical-trial results corroborated the jaw-dropping initial numbers: Patients lost on average 71 pounds, or 29 percent of their body weightdouble what people lose on semaglutide, which is better known as Ozempic or Wegovy